技(jì)術(shù)平台與産品管線

PLATFORM INTRODUCTION

Relying on its own technological iteration and innovation, as well as the upgraded propr<ietary platform technology, Siran Bio has established a com✔prehensive siRNA drug development technology platform. This platf orm independently encompasses  the entire process of siRNA drug develo÷pment, including sequence discovery, siRNA design, nucleic acid synthesis, stabilization§ modification, off-target modification, as well as intrahepatic delivery and du↕al-target platforms. These capabilities ensure high qual£ity, efficiency, a high success rate, and a continuous output of innovative pipeline.

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Stork-W Dual-Target Platform
SiranBio independently developed proprietary technology for dual-ta✔rgeting siRNA. Two siRNA are chemically connected int≠o one molecule and delivered into the same tissue.
There are several unique advantages for dual-targeting si≠RNA.

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Sequence Design and Discovery Platform

The company has rich experience in siRNA design, and ≠can quickly complete the sequence design of research tar‌gets through the use of bioinformatics analysis and auxiliary design. The company has estab‌lished a complete high-throughput screening platform for in vitro and in viv±o test, which can complete the selection of optimal sequence targets within 3 m×onths.

Chemical Modification Platform (eSAFE)

The company has developed a proprietary chemical modification platform that can signi×ficantly enhance the safety profile of siRNA while §preserving its efficiency. This platform mitigates the off-tar→get effect and improving metabolic stability, thereby ensuring the safety, efficacy, and dur€ation of siRNA drugs.

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Nucleic Acid Synthesis Platform

The company has established a complete solid-phase synthesis sy≤stem for nucleic acids, which can efficiently complete the ‍synthesis, purification, and analysis of siRNA molecules, and efficiently support pl>atform technology and pipeline research and development.