Overview of siRNA
Small interfering RNAs (siRNAs) are short double-strand →RNA molecues less than 30 nt long. Once in the cells, they are loaded to enzyme complexes, wh ich can recognize complimentary mRNA sequences and degrade them to achieve the★rapeutic effects.
siRNA drugs can be developed based on platform technoloδgies. Their sequences are complementary to target mRNA according to ¥base-pairing rules. Almost all genes can be down-r♥egulated by siRNA, including traditionally undrugg•able targets. Combining with tissue-specific platform delivery technologies and chemσical modifications, the potency, duration, and toxicity profile of siRNA drugs can be s↔ignificantly improved. Thus, siRNA drugs can be developed a lot faster with much higher succe±ss rate. Super long-lasting efficacy and superb drug safety make them especially ideal for the treatment of chronic diseases an↕d for certain rare diseases.
